Blar i forfatter "Siganos, Galatios"
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Effect of major lifestyle risk factors, independent and jointly, on life expectancy with and without cardiovascular disease: results from the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES)
O'Doherty, Mark G.; Cairns, Karen; O'Neill, Vikki; Lamrock, Felicity; Jørgensen, Torben; Brenner, Hermann; Schöttker, Ben; Wilsgaard, Tom; Siganos, Galatios; Kuulasmaa, Kari; Boffetta, Paolo; Trichopoulou, Antonia; Kee, Frank (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-18)Seldom have studies taken account of changes in lifestyle habits in the elderly, or investigated their impact on disease-free life expectancy (LE) and LE with cardiovascular disease (CVD). Using data on subjects aged 50+ years from three European cohorts (RCPH, ESTHER and Tromsø), we used multi-state Markov models to calculate the independent and joint effects of smoking, physical activity, obesity ... -
HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confoundersin a meta-analysis of individual participant data from six cohort studies
Schöttker, Ben; Rathmann, Wolfgang; Herder, Christian; Thorand, Barbara; Wilsgaard, Tom; Njølstad, Inger; Siganos, Galatios; Mathiesen, Ellisiv B.; Saum, Kai-Uwe; Peasey, Anne; Feskens, Edith J.M.; Boffetta, Paolo; Trichopoulou, Antonia; Kuulasmaa, Kari; Kee, Frank; Brenner, Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-11)Background:<br>To determine the shape of the associations of HbA1c with mortality and cardiovascular outcomes in non-diabetic individuals and explore potential explanations.<br> Methods:<br> The associations of HbA1c with all-cause mortality, cardiovascular mortality and primary cardiovascular events (myocardial infarction or stroke) were assessed in non-diabetic subjects ≥50 years from six ... -
Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States
Schöttker, B; Jorde, Rolf; Peasey, A; Thorand, B; Jansen, EH; De Groot, L.; Streppel, M; Gardiner, J; Ordóñez-Mena, JM; Perna, L; Wilsgaard, Tom; Rathmann, W; Feskens, E; Kampman, E; Siganos, Galatios; Njølstad, Inger; Mathiesen, Ellisiv B.; Kubínová, R; Pajak, A; Topor-Madry, R; Tamosiunas, A; Hughes, M; Kee, F; Bobak, M; Trichopoulou, A; Boffetta, P; Brenner, H (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-17)Objective To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences.<p> <p>Design Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US. <p>Setting General population. <p>P ...